Physiology of nociception
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چکیده
Like most reviews on the pathophysiology of pain this lecture will mainly consider the physiology of nociceptiono Nociception like other sensory modalities is subserved by a specific array of nervous connexions which have been known in broad lines for many yearso A number ofneurosurgical operating procedures (cordotomy, tractotomy .oo) were based on this' knowledge. In recent years owing to major experimental findings (opioid receptors, endogenous opioid substances oo.) and theoretical efforts (gate control theory oo.) a new paradigm has emerged for the comprehension of pain. Mechanisms underlying the extraordinary plasticity-of human pain are better understood and many new therapeutical approaches have been proposed.
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